Fulvine and the pulmonary circulation
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Fulvine and the pulmonary circulation.
The pyrrolizidine alkaloid, fulvine, is now accepted as a major cause of veno-occlusive disease of the liver in the West Indies, where it is ingested as a decoction of the plant Crotalaria fulva in bush tea. Fulvine is similar in chemical structure to monocrotaline, which is known to cause pulmonary hypertension in rats. Thirty young female rats were given a single dose of fulvine either by int...
متن کاملElectron microscopy of pulmonary vasculature after application of fulvine.
Wagenvoort, C. A., Dingemans, K. P., and Lotgering, G. G. (1974). Thorax, 29, 511-521. Electron microscopy of pulmonary vasculature after application of fulvine. This is an electron microscopic study of the effect of fulvine on the pulmonary arteries and veins of the rat. Marked constriction of the arteries was evident from excessive crenation of the interial elastic membrane, resulting in sque...
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ژورنال
عنوان ژورنال: Thorax
سال: 1971
ISSN: 0040-6376
DOI: 10.1136/thx.26.3.249